Aortic & peripheral vascular diseaseMeta-analysis
1-Year Outcomes of Transcatheter Arterialization of Deep Veins
- Prospective single-arm study with patient-level pooled analysis
- multicentre
Authors' conclusion
1-year outcomes following TADV with the LimFlow System demonstrated durable AFS and limb salvage rates, and improvement in clinical symptoms in no-option CLTI patients who often face major amputation or palliative care.
Study context
- Population
- Patients with Rutherford class 5/6 chronic limb-threatening ischemia (CLTI) and independently assessed no-option statuspooled analysis n = 137
- Participants
- 105 patients
- Outcome
- Amputation-free survival (AFS), limb salvage and survival
- Follow-up
- 1 year
Pooled result
As reported in the abstract
AFS, limb salvage and survival (PROMISE II)
Amputation-free survival (AFS)
54.2% (95% CI: 45.2-65.1%)
Limb salvage
68.7% (95% CI: 59.8-78.9%)
Survival
79.0% (95% CI: 70.2-88.8%)
Further pooled results
AFS, limb salvage and survival (pooled PROMISE I, II and UK, n = 137) · 1 year
- AFS
- 66.1% (95% CI: 58.4-74.9%)
- Limb salvage
- 74.4% (95% CI: 67.1-82.5%)
- Survival
- 88.9% (95% CI: 82.9-95.2%)
- patient-level pooled analysis
Clinical symptoms and wound status · 1 year
- Clinical symptoms and wound status showed improvement through 1 year
Original publication
1-Year Outcomes of Transcatheter Arterialization of Deep Veins. JACC Cardiovasc Interv. Published 14 July 2025. doi:10.1016/j.jcin.2025.05.004
Summarised from the published abstract; every number is checked against it