Coronary disease & ACSCohort study
10-Year Mortality After ST-Segment Elevation Myocardial Infarction Compared to the General Population
- Registry-based matched cohort study
- age- and sex-matched general population
- landmark analysis
- Western Denmark Heart Registry
Authors' conclusion
In primary PCI-treated STEMI patients with high use of guideline-recommended therapy, patients surviving the first 90 days had 10-year mortality that was only 2% higher than that of a matched general population.
Study context
- Population
- First-time percutaneous coronary intervention (PCI)-treated patients with primary PCI for STEMI, Western Denmark Heart Registry, January 2003 to October 2018
- Participants
- 18,818 vs 94,090
- Exposure
- Primary PCI-treated STEMI vs age- and sex-matched general population
- STEMIn = 18,818
- General populationn = 94,090reference
- Outcome
- Excess mortality at landmark periods 0–30 days, 31–90 days and 91 days to 10 years
- Follow-up
- 10 years
Main finding
As reported in the abstract
Mortality, 91 days to 10 years (90-day survivors) · 10-year follow-up
Hazard ratio
1.04
95% CI 1.01–1.08
By group
STEMI vs General population
HR 1.04 (95% CI 1.01–1.08)
Observational data: associations, not effects.
Further findings
| Outcome | STEMI | General population | HR (95% CI) | |
|---|---|---|---|---|
| Mortality · 0 to 30 days · 5.9% excess mortality | 6.0% | Not reported in the abstract | 36.44 (30.86–43.04) | |
| Mortality · 31 to 90 days | 0.9% | Not reported in the abstract | 2.43 (2.02–2.93) | |
| 0.050.21520Hazard ratio (log scale) |
- Mortality: Matched individuals 0.2%
- Mortality: Matched individuals 0.4%
Original publication
10-Year Mortality After ST-Segment Elevation Myocardial Infarction Compared to the General Population. J Am Coll Cardiol. Published 25 June 2024. doi:10.1016/j.jacc.2024.04.025
Summarised from the published abstract; every number is checked against it