Coronary disease & ACSSecondary analysis
10-Year Outcome of Complete or Infarct Artery-Only Revascularization in STEMI With Multivessel Disease
- Secondary analysis of the DANAMI-3-PRIMULTI randomised trial
- 10-year follow-up
Authors' conclusion
FFR-guided complete revascularization reduced future and repeated events compared with infarct-related artery only after 10 years.
Study context
- Population
- Patients with STEMI and ≥1 angiographically significant non-infarct-related lesion
- Participants
- 627 patients
- Comparison
- Fractional flow reserve (FFR)-guided complete revascularization vs infarct-related artery only
- Complete revascularizationn = 314
- Infarct-related artery onlyn = 313reference
- Primary endpoint
- Composite of:
- All-cause mortality
- Recurrent MI
- Any revascularization
- Follow-up
- 10 years
Primary result
As reported in the abstract
Hazard ratio
0.76
95% CI 0.60–0.94
P = 0.014
Complete revascularization vs Infarct-related artery only
HR 0.76 (95% CI 0.60–0.94); P = 0.014
Further findings
All-cause death · 10 years
| Outcome | OR (95% CI) | |
|---|---|---|
| Any revascularization · 10 years | 0.62 (0.44–0.89) | |
| 0.512Odds ratio (log scale) |
Mean cumulative number, per 100 persons
| Outcome | Complete revascularization | Infarct-related artery only | absolute reduction (%) (95% CI) | |
|---|---|---|---|---|
| Mean cumulative number of events (repeated events) · 10 years | 63 (95% CI 54–73) | 76 (95% CI 66–88) | 13 (−1% to 28%) | |
| −2002040Difference, % (linear scale) |
Recurrent MI · 10 years
- No difference in recurrent MI
- OR: 0.90; 95% CI: 0.60-1.35
Original publication
10-Year Outcome of Complete or Infarct Artery-Only Revascularization in STEMI With Multivessel Disease. J Am Coll Cardiol. Published 20 May 2025. doi:10.1016/j.jacc.2025.05.013
Summarised from the published abstract; every number is checked against it