Cardiometabolic & kidneyCase-control study
2-Fold More Cardiovascular Disease Events Decades Before Type 2 Diabetes Diagnosis
- Combined case-control and cohort study
- age- and sex-matched
- nationwide (Denmark)
Authors' conclusion
Individuals with T2DM had 2-fold more CVD events than matched comparisons starting 3 decades before T2DM diagnosis.
Study context
- Population
- Individuals diagnosed with T2DM in Denmark between 2010 and 2015 and age- and sex-matched general population comparisons
- Participants
- 127,092 vs 381,023
- Comparison
- Individuals with T2DM vs matched general population comparisons
- T2DMn = 127,092
- Comparisonsn = 381,023reference
- Outcome
- CVD (MI or ischemic stroke) occurrence before and after T2DM diagnosis
- Follow-up
- 30 years before and 5 years after T2DM diagnosis
Main finding
As reported in the abstract
CVD prevalence before T2DM diagnosis · 30-year period before T2DM diagnosis
T2DM vs ComparisonsEstimate (95% CI)
earliest period (25-30 years before diagnosis)
OR 2.18(1.91–2.48)
latest period (<5 years before diagnosis)
OR 2.96(2.85–3.08)
5-year CVD incidence after T2DM diagnosis
HR 2.20(2.12–2.27)
Observational data: associations, not effects.
Original publication
2-Fold More Cardiovascular Disease Events Decades Before Type 2 Diabetes Diagnosis. J Am Coll Cardiol. Published 3 December 2024. doi:10.1016/j.jacc.2024.06.050
Summarised from the published abstract; every number is checked against it