Cross-sectional study
3-Dimensional Strain Analysis of Hypertrophic Cardiomyopathy
- Cross-sectional study
- registry-based
Authors' conclusion
Abnormal strain in hypertrophic cardiomyopathy is associated with other imaging and serum biomarkers of increased risk.
Study context
- Population
- Patients with hypertrophic cardiomyopathy in the National Heart, Lung, and Blood Institute (NHLBI) Hypertrophic Cardiomyopathy Registry (HCMR), baseline data; 3D left ventricular (LV) strain by cine CMR feature tracking
- Participants
- 2,311 patients
- Exposure
- Abnormal vs normal global longitudinal strain (GLS)
- Outcome
- Predictors of abnormal GLS
- Follow-up
- Baseline
Main finding
As reported in the abstract
Imaging markers by GLS status
| Group | LV mass index | Maximal wall thickness | LVEF | RV EF |
|---|---|---|---|---|
| Abnormal GLS | 93.8 ± 29.2 g/m² | 21.7 ± 5.2 mm | 62% ± 9% | 68% ± 11% |
| Normal GLS | 75.1 ± 19.7 g/m² | 19.3 ± 4.1 mm | 66% ± 7% | 69% ± 10% |
- Abnormal GLS vs Normal GLS: P < 0.0001 — LV mass index
- Abnormal GLS vs Normal GLS: P < 0.0001 — maximal wall thickness
- Abnormal GLS vs Normal GLS: P < 0.0001 — LVEF
- Abnormal GLS vs Normal GLS: P < 0.01 — RV EF
- Lower left atrial emptying functions with abnormal GLS
- P < 0.0001 for all
- Higher presence and myocardial extent of late gadolinium enhancement with abnormal GLS (6 SD and visual quantification)
- P < 0.0001 for both
Observational data: associations, not effects.
Original publication
3-Dimensional Strain Analysis of Hypertrophic Cardiomyopathy. JACC Cardiovasc Imaging. Published 14 December 2022. doi:10.1016/j.jcmg.2022.10.005
Summarised from the published abstract; every number is checked against it