Valvular & structural heart diseaseRandomised controlled trial
5-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis
- Randomised controlled trial
Authors' conclusion
At 5 years, patients with severe aortic stenosis who were treated with either TAVR or surgery had comparable rates of all-cause mortality or disabling stroke.
Study context
- Population
- Low-risk patients with severe AS (Evolut Low Risk trial)attempted implant
- Participants
- 1,414 patients
- Comparison
- Transcatheter aortic valve replacement (TAVR) vs surgery
- TAVRn = 730
- Surgeryn = 684reference
- Primary endpoint
- All-cause mortality or disabling stroke
- Follow-up
- 5 years
Primary result
As reported in the abstract
All-cause mortality or disabling stroke (Kaplan-Meier estimate)
P = 0.47
Secondary outcomes
All-cause mortality (Kaplan-Meier estimate) · 5 years
P = 0.39
Disabling stroke (Kaplan-Meier estimate) · 5 years
P = 0.57
CV mortality · 5 years
P = 0.15
Non-CV mortality · 5 years
P = 0.73
All-cause mortality incl. site-level vital status sweep of patients lost to follow-up or withdrawn · 5 years
P = 0.74
Valve reintervention · 5 years
P = 0.44
Mean
| Outcome | TAVR | Surgery | P value |
|---|---|---|---|
| Kansas City Cardiomyopathy Questionnaire summary score · 5 years · sustained improvement in QoL in both arms | 88.3 (SD 15.8) | 88.5 (SD 15.8) |
Original publication
5-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis. J Am Coll Cardiol. Published 30 March 2025. doi:10.1016/j.jacc.2025.03.004
Summarised from the published abstract; every number is checked against it