Coronary disease & ACSRandomised controlled trial
A comprehensive analysis of the impact of high-intensity interval vs. moderate-intensity continuous training on global and regional myocardial function in patients early after acute myocardial infarction: the STRAICT randomized controlled trial
- Randomised controlled trial
Authors' conclusion
Early supervised exercise-based CR, whether using MICT or isovolumic HIIT, improves longitudinal myocardial function in both culprit and non-culprit territories after AMI.
Study context
- Population
- Patients early after acute MI (training started within 6 weeks post-MI)
- Participants
- 100 participants
- Comparison
- Isovolumic high-intensity interval training (HIIT) vs moderate-intensity continuous training (MICT)
- HIITn = 50
- MICTn = 50reference
- Primary endpoint
- LV myocardial function by speckle-tracking echocardiography (global longitudinal strain (LS) and other deformation indexes)
- Follow-up
- After 8-week CR
Primary result
As reported in the abstract
Global LS change · after CR
HIIT
−0.82%
95% CI −0.19/−61
MICT
−1.11%
95% CI −1.17/−0.51
P = 0.71
- Myocardial work (MW) index and efficiency, constructive MW, post-systolic shortenings (PSS) number and wasted MW improved similarly
- time ∗ group P > 0.12
- Improvements in all territories regardless of culprit vessel
- P > 0.60
Further findings
Left ventricular (LV) torsion · after cardiac rehabilitation (CR)
- Circumferential strains unchanged in both groups; trend for torsion to decrease with MICT (P = 0.06) and increase with HIIT (P = 0.36)
- time ∗ group P = 0.04
Left atrial reservoir and conduit strains · after CR
- Improved similarly in MICT vs HIIT
- time ∗ group P > 0.54
V̇O2peak and quality of life · after CR
- V̇O2peak improved equally in MICT and HIIT
- P < 0.001
- Quality of life improved equally in MICT and HIIT
- P < 0.001
Original publication
A comprehensive analysis of the impact of high-intensity interval vs. moderate-intensity continuous training on global and regional myocardial function in patients early after acute myocardial infarction: the STRAICT randomized controlled trial. Eur J Prev Cardiol. Published 5 March 2025. doi:10.1093/eurjpc/zwaf127
Summarised from the published abstract; every number is checked against it