Cardio-oncology & otherSecondary analysis
A Contemporary Picture of Coagulase-Negative Staphylococcal Endocarditis
- Post hoc analysis of a prospective cohort study (GAMES cohort)
- prospectively collected
- multicentre
- nationwide
- 44 Spanish centres
- 2008–2022
Authors' conclusion
CoNSIE was a relatively common (18.4%) and life-threatening entity with particularities by species yet generally high rates of surgery and mortality, although its prognosis improved over time.
Study context
- Population
- Consecutive definitive infective endocarditis episodes, 44 Spanish centres, 2008–2022
- Participants
- 4,567 definitive infective endocarditis (IE) episodes
- Comparison
- Coagulase-negative staphylococcal IE (CoNSIE) vs SAIE
- CoNSIEn = 842
- SAIEn = 1,109reference
- SEn = 647
- SLn = 54
- Other coagulase-negative staphylococci (CoNS)n = 109
- Primary endpoint
- In-hospital and 1-year mortality
Primary result
As reported in the abstract
In-hospital mortality, CoNSIE vs SAIE
P = 0.049
Further findings
Staphylococcal share of IE episodes
- Staphylococci accounted for 1,951 episodes of IE
- 42.7%
- SE share of CoNS etiology
- 76.8%
- SL share of CoNS etiology
- 6.4%
Cardiac surgery rates, SL vs SE vs other CoNS
- Cardiac surgery rates high and similar in all groups (60.4% vs 61.1% vs 56.0%)
- P = 0.850
In-hospital mortality, SL vs SE vs other CoNS
- In-hospital mortality high and similar in all groups (33.1% vs 37.0% vs 27.5%)
- P = 0.540
- 1-year mortality high and similar in all groups
Independent prognostic factors for mortality
- Septic shock, HF and cardiac surgery (protective) independent prognostic factors; no staphylococcal species independently associated with mortality
- Each 5-year study period independently associated with reduced in-hospital and 1-year mortality
Original publication
A Contemporary Picture of Coagulase-Negative Staphylococcal Endocarditis. J Am Coll Cardiol. Published 22 November 2024. doi:10.1016/j.jacc.2024.09.027
Summarised from the published abstract; every number is checked against it