A Diagnostic Paradigm Shift in Acute Myocardial Infarction: Rationale and Design of the DIFOCCULT-3 Trial
Authors' conclusion
The DIFOCCULT-3 study aims to determine whether the OMI/NOMI paradigm represents a significant advancement in MI care by improving outcomes through earlier and more accurate identification of ACO than the STEMI/NSTEMI framework
Study context
- Population
- Participants presenting with suspected myocardial infarction (MI)planned
- Participants
- 6,000 participants
- Comparison
- Occlusive MI (OMI)/nonocclusive MI (NOMI) paradigm vs STEMI/NSTEMI approach
- Primary endpoint
- Composite of:
- All-cause mortality
- All-cause rehospitalization
- Follow-up
- 1-year follow-up
Methodological detailsdesign paper, multicenter, modified cluster-randomized, open-label
- Design paper
- Multicenter
- Modified cluster-randomized
- Open-label
Primary result
As reported in the abstract
- Enrollment and follow-up are ongoing; no results reported
Original publication
A Diagnostic Paradigm Shift in Acute Myocardial Infarction: Rationale and Design of the DIFOCCULT-3 Trial. JACC Adv. Published 22 October 2025. doi:10.
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