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Heart failure & cardiomyopathiesResearch article

A Hemodynamic Echocardiographic Approach to Disease Severity and Prognosis in Transthyretin Amyloid Cardiomyopathy

JACC AdvPublished

  • noninvasive hemodynamic echocardiographic approach to stratify patients with ATTR-CM
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Authors' conclusion

The noninvasive hemodynamic approach provides an alternative and promising method to stratify the risk of clinical outcome in patients with ATTR-CM, potentially improving management strategies.

Study context

Population
Patients with transthyretin amyloid cardiomyopathy (ATTR-CM)patients with ATTR-CM · group 1 115 · group 2 129 · group 3 49
Participants
293 patients
Comparison
Hemodynamic staging groups based on stroke volume index (SVi) and systolic pulmonary artery pressure (sPAP); cutoffs 30 mL/m² for SVi and 40 mm Hg for sPAP
  • group 1n = 115reference
  • group 2n = 129
  • group 3n = 49
Outcome
Composite of:
  • All-cause mortality
  • Heart failure hospitalization

Main finding

As reported in the abstract

multivariable Cox regression adjusted for age, sex, and disease-modifying therapy; P printed for the staging system
Each group vs group 1Hazard ratio (95% CI)P value
group 2
1.70(1.05–2.71)
P < 0.001
group 3
2.50(1.44–4.30)
P < 0.001
Primary outcome occurred in
108 (37%) patients

Original publication

A Hemodynamic Echocardiographic Approach to Disease Severity and Prognosis in Transthyretin Amyloid Cardiomyopathy. JACC Adv. Published 22 September 2026. doi:10.1016/j.jacadv.2026.103244
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Summarised from the published abstract; every number is checked against it