Coronary disease & ACSRandomised controlled trial
A Multidomain Lifestyle Intervention for Invasively Confirmed ANOCA
- Randomised controlled trial
- prospective
- multicentre
- blinded endpoint assessment
Authors' conclusion
In patients with invasively confirmed ANOCA, a structured multidomain lifestyle intervention provided clinically meaningful improvements in patient-reported health status on top of endotype-guided medical therapy.
Study context
- Population
- Patients with angina and invasive evidence of coronary microvascular dysfunction and/or coronary vasomotor disorder (ANOCA)
- Participants
- 123 patients
- Comparison
- Intervention vs Control
- Interventionn = 62
- Controln = 61reference
- Primary endpoint
- Change in Seattle Angina Questionnaire summary score
- Follow-up
- 12 months
Primary result
As reported in the abstract
Seattle Angina Questionnaire summary score (adjusted mean improvement)
Between-group difference
13.12 points
95% CI 9.68–16.56
P < 0.001
Intervention vs Control
between-group difference 13.12 points (95% CI 9.68–16.56); P < 0.001
Further findings
| Outcome | Intervention | Control | adjusted risk ratio (95% CI) | P value | |
|---|---|---|---|---|---|
| Clinically meaningful improvement in SAQ summary score (≥10-point increase) · 12 months | 77% | Not reported in the abstract | 1.98 (1.20–3.26) | P < 0.001 | |
| 0.20.5125Adjusted risk ratio (log scale) |
EuroQol 5-Dimension 5-Level index and Beck Depression Inventory scores
- Significant improvements with intervention
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A Multidomain Lifestyle Intervention for Invasively Confirmed ANOCA. JACC Cardiovasc Interv. Published 27 July 2026. doi:10.1016/j.jcin.2026.05.021
Summarised from the published abstract; every number is checked against it