Prevention & lipidsResearch article
A Novel Approach to Manage Hypercholesterolemia
- Quality Improvement
- embedded in the usual clinical care
- 50 Veterans Affairs Medical Centers
Authors' conclusion
This program showed that addressing site-specific barriers to lipid management is associated with improved LDL-C among Veterans with ASCVD.
Study context
- Population
- Veterans with prevalent atherosclerotic cardiovascular disease (ASCVD) and baseline low-density lipoprotein cholesterol (LDL-C) ≥70 mg/dL, Veterans Affairs Medical Centers, December 2022 to September 2025veterans with baseline LDL-C ≥70 mg/dL included in current analyses, of 167,505 veterans with prevalent ASCVD, 24,610 with 24-month LDL-C data
- Participants
- 88,778 veterans
- Comparison
- Between baseline and follow-up LDL-C measurement at 24 months, with strategies tailored to site-identified barriers to lipid management
- Outcome
- Proportion of veterans with LDL-C <70 mg/dL
- Follow-up
- 24 months
Main finding
As reported in the abstract
Veterans achieving LDL-C <70 mg/dL, overall
32.9%
Of the 24,610 veterans with 24-month LDL-C data, achieving LDL-C goal
34.4%
Further findings
Mean LDL-C · between baseline and 24 months
- Mean LDL-C decreased by
- 16.6 mg/dL
Use of lipid-lowering therapy (LLT) · between baseline and 24 months
- Use of LLT increased from
- 77.4% to 87.8%
Adherence to any LLT · between baseline and 24 months
- Adherence to any LLT increased from
- 56.3% to 65.1%
Original publication
A Novel Approach to Manage Hypercholesterolemia. JACC Adv. Published 18 June 2026. doi:10.1016/j.jacadv.2026.102935
Summarised from the published abstract; every number is checked against it