Heart failure & cardiomyopathiesDiagnostic or prognostic study
A novel polygenic risk score improves prognostic prediction of heart failure with preserved ejection fraction in the Chinese Han population
- Prognostic model development study
- microarray candidate gene selection
- internal cross-validation
Authors' conclusion
The HF-PRS comprising 69 genetic variants provided an improvement of prognostic power over the contemporary risk scores and NT-proBNP in HFpEF patients.
Study context
- Population
- HFpEF patients, Chinese Han population
- Participants
- 1,442 patients
- Comparison
- HF-PRS vs clinical risk score
- Outcome
- All-cause mortality
- Follow-up
- 1 year
Performance
As reported in the abstract
Discrimination for 1-year all-cause mortality
HF-PRS
0.852 (95% CI 0.827-0.877)
AUC
Clinical risk score
0.696 (95% CI 0.658-0.734)
AUC
- HF-PRS
- Net reclassification improvement (NRI) 0.741 (95% CI 0.605–0.877); P < 0.001
- HF-PRS
- Integrated discrimination improvement (IDI) 0.181 (95% CI 0.145–0.218); P < 0.001
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality by HF-PRS tertile — Medium tertile vs Lowest tertile | 5.3 (2.4–11.9) | P = 5.6 × 10-5 | |
| Mortality by HF-PRS tertile — Highest tertile vs Lowest tertile | 29.8 (14.0–63.5) | P = 1.4 × 10-18 | |
| 0.050.21520Hazard ratio (log scale) |
Discrimination in cross-validation and subgroups
- Excellent in cross validation and throughout subgroups regardless of comorbidities, gender, and history of heart failure (HF)
Original publication
A novel polygenic risk score improves prognostic prediction of heart failure with preserved ejection fraction in the Chinese Han population. Eur J Prev Cardiol. Published 21 June 2023. doi:10.1093/eurjpc/zwad209
Summarised from the published abstract; every number is checked against it