Arrhythmias & electrophysiology
A novel predictive model for left atrial low-voltage areas in paroxysmal atrial fibrillation
Authors' conclusion
The HeSLeF-PC score could effectively predict the presence of left atrial LVAs in patients with paroxysmal AF and may assist in preprocedural risk stratification and ablation planning.
Study context
- Population
- Patients with paroxysmal atrial fibrillation (AF) receiving their initial radiofrequency ablation in the Department of Cardiology at Shanghai East Hospitalpatients with paroxysmal AF enrolled (derivation cohort)
- Participants
- 383 patients
- Index test or model
- HeSLeF-PC score vs low-voltage areas (LVAs) on left atrial voltage mapping
- Target condition
- Left atrial low-voltage areas (LVAs)
Methodological detailsindependent prospective validation cohort, multicenter validation cohort
- Independent prospective validation cohort
- Multicenter validation cohort
Performance
As reported in the abstract
| Test or model | AUROC |
|---|---|
| Derivation cohort | 0.810 (95% CI 0.762-0.859) |
| Prospective cohort | 0.826 (95% CI 0.757-0.896) |
| Multicenter cohort | 0.767 (95% CI 0.678-0.857) |
AUROC
Derivation cohort0.810 (95% CI 0.762-0.859)
Prospective cohort0.826 (95% CI 0.757-0.896)
Multicenter cohort0.767 (95% CI 0.678-0.857)
Further findings
Clinical utility
- Decision curve analysis confirmed its clinical utility
Prevalence of left atrial LVAs
- Patients with left atrial LVAs, of the 383 enrolled
- 104 patients (27.2%)
Independent predictors of LVAs (multivariate logistic regression)
- Female sex, prior stroke, left atrial diameter, PR interval, hemoglobin level, and serum creatinine level
Original publication
A novel predictive model for left atrial low-voltage areas in paroxysmal atrial fibrillation. Heart Rhythm. Published 6 February 2026. doi:10.
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