Coronary disease & ACSRandomised controlled trial
A nurse-coordinated intervention programme vs standard of care after an acute coronary syndrome: the ALLEPRE trial
- Randomised controlled trial
- pragmatic
- multicentre
Authors' conclusion
The NCPP significantly reduced long-term MACE, improved physical activity, body weight control, and pharmacotherapy adherence in post-hospitalization ACS patients.
Study context
- Population
- Patients after acute coronary syndrome (ACS)
- Participants
- 2,057 patients
- Comparison
- Nurse-coordinated prevention programme vs standard of care
- Nurse-coordinated prevention program (NCPP)n = 1,031
- Standard of care (SOC)n = 1,026reference
- Primary endpoint
- MACE:
- CV death
- Non-fatal myocardial infarction (MI)
- Non-fatal stroke
Primary result
MACE
Hazard ratio
0.70
95% CI 0.57–0.85
P < 0.001
By group
NCPP vs SOC
HR 0.70 (95% CI 0.57–0.85); P < 0.001
As reported in the abstract
Secondary outcomes
| Outcome | NCPP | SOC | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Non-fatal MI (MACE component) | 9.3% | 15.2% | 0.60 (0.46–0.77) | P = 0.0001 | |
| 0.512Hazard ratio (log scale) |
MACE plus ischaemia-driven revascularization (pre-specified secondary)
- Significantly reduced; HR (95% CI)
- HR 0.77, 95% CI 0.64-0.92; P-value= 0.005
Exercise frequency, body weight control, medication adherence
- Exercise frequency improved more with NCPP
- P < 0.0001
- Body weight control improved more with NCPP
- P = 0.003
- Medication adherence improved more with NCPP
- P < 0.001
Original publication
A nurse-coordinated intervention programme vs standard of care after an acute coronary syndrome: the ALLEPRE trial. Eur Heart J. Published 5 May 2026. doi:10.1093/eurheartj/ehag255
Summarised from the published abstract; every number is checked against it