Coronary disease & ACSRandomised controlled trial
A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina
- Randomised controlled trial
- double-blind
- placebo-controlled
Authors' conclusion
Among patients with stable angina who were receiving little or no antianginal medication and had objective evidence of ischemia, PCI resulted in a lower angina symptom score than a placebo procedure, indicating a better health status with respect to angina.
Study context
- Population
- Patients with stable angina off all antianginal medications, with objective evidence of ischemia
- Participants
- 301 patients
- Comparison
- Percutaneous coronary intervention (PCI) vs placebo procedure
- PCIn = 151
- Placebon = 150reference
- Primary endpoint
- Angina symptom score (daily; angina episodes, antianginal medications, clinical events; range 0–79, higher = worse)
- Follow-up
- 12 weeks
Primary result
Mean angina symptom score
Odds ratio
2.21
95% CI 1.41–3.47
P < 0.001
By group
PCI
2.9
mean
Placebo
5.6
mean
PCI vs Placebo
OR 2.21 (95% CI 1.41–3.47); P < 0.001
As reported in the abstract
Safety
events
| Outcome | PCI | Placebo |
|---|---|---|
| ACS | 4 | 6 |
| Unacceptable angina leading to unblinding | Not reported in the abstract | 1 |
Original publication
A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina. N Engl J Med. Published 11 November 2023. doi:10.1056/nejmoa2310610
Summarised from the published abstract; every number is checked against it