Prevention & lipidsResearch article
A practical guide to target trial emulation: connecting randomized trials and real-world data in cardiovascular research
- Narrative review
Authors' conclusion
TTE strengthens the credibility of real-world evidence by improving transparency, reducing avoidable design biases, and aligning analyses with clinically meaningful decisions.
Main finding
As reported in the abstract
Role of TTE in cardiovascular prevention research (narrative review)
- Target trial emulation (TTE) strengthens credibility of real-world evidence by improving transparency, reducing avoidable design biases and aligning analyses with clinically meaningful decisions
- TTE does not eliminate residual confounding; complementary to, not a substitute for, randomised evidence
Original publication
A practical guide to target trial emulation: connecting randomized trials and real-world data in cardiovascular research. Eur J Prev Cardiol. Published 23 May 2026. doi:10.1093/eurjpc/zwag267
Summarised from the published abstract; every number is checked against it