Heart failure & cardiomyopathiesGuideline or statement
A Roadmap for Therapeutic Discovery in Pulmonary Hypertension Associated with Left Heart Failure. A Scientific Statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function
- Scientific statement
Recommendations
As issued by the authors
Better understanding of the role of pulmonary venous vs arteriolar remodelling
Multidimensional phenotyping to recognise patient subgroups positioned to respond to different therapies
Rigorous pre-clinical studies combining small and large animal models
Enrichment strategies, endpoint assessments and thorough haemodynamic studies, at rest and during exercise, to optimise early-stage development of candidate therapies for PH-LHF
Original publication
A Roadmap for Therapeutic Discovery in Pulmonary Hypertension Associated with Left Heart Failure. A Scientific Statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function. Eur J Heart Fail. Published 19 April 2024. doi:10.1002/ejhf.3236
Summarised from the published abstract; every number is checked against it