Acute cardiac care & resuscitationMeta-analysis
A systematic review of mortality and severe morbidities following newborn chest compressions at birth
- systematic review
Authors' conclusion
The substantial variation in CC outcome estimates cannot be reliably ascribed to temporal or geographic factors, given the heterogeneity in inclusion criteria. Persistent gaps in differentiating DR deaths and stratifying outcomes by gestation, birth setting, care level, and CC timeliness underscore the need for prospective studies aligned with the Neonatal Utstein to improve precision and comparison of evidence in neonatal resuscitation.
Study context
- Population
- Newborns receiving delivery room chest compressions at birthChest compressions (CC) recipients, Twenty-six studies, 1989–2019, 16 high-income countries
- Participants
- 9,747 newborns
- Outcome
- Mortality
Pooled result
As reported in the abstract
Mortality among moderate and late preterm infants
21%
Mortality among very preterm or very low birth weight infants
27-74%
Mortality in studies with definitions that also required epinephrine
39-74%
Further pooled results
Severe neurological injury (NI)
- Severe NI range
- 16% and 42%
- Severe NI in studies with definitions that also required epinephrine
- 19-42%
Evidence gaps
- Evidence from low- and middle-income countries and for late preterm, term, and outborn infants, by care level, and by CC timeliness was sparse
Original publication
Summarised from the published abstract; every number is checked against it