Abbreviated or Standard Antiplatelet Therapy in HBR Patients: Final 15-Month Results of the MASTER-DAPT Trial
Authors' conclusion
At 15 months, NACE and MACCE did not differ in the 2 study groups, whereas the risk of major or clinically relevant nonmajor bleeding remained lower with abbreviated compared with standard APT.
Study context
- Population
- High bleeding risk patients after percutaneous coronary intervention (PCI); outcomes including routine care after the randomised phase
- Participants
- 4,579 participants
- Comparison
- Abbreviated vs standard antiplatelet therapy (APT)
- Abbreviatedn = 2,295
- Standardn = 2,284reference
- Primary endpoint
- Coprimary: NACE (all-cause death, MI, stroke, BARC 3 or 5 bleeding); MACCE (all-cause death, MI, stroke); BARC type 2, 3 or 5 bleeding
- Follow-up
- 15 months (cumulative) and 12 to 15 months
Primary result
As reported in the abstract
15 months
Abbreviated vs StandardHazard ratio (95% CI)P value
NACE
0.92(0.76–1.12)
P = 0.399MACCE
0.94(0.76–1.17)
P = 0.579BARC 2, 3 or 5 bleeding
0.68(0.56–0.83)
P = 0.0001Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| NACE, MACCE and BARC 2, 3 or 5 bleeding during routine care period · 12 to 15 monthsAbbreviatedvs StandardNACE | 0.81 (0.50–1.30) | P = 0.387 | |
| NACE, MACCE and BARC 2, 3 or 5 bleeding during routine care period · 12 to 15 monthsAbbreviatedvs StandardMACCE | 0.74 (0.43–1.26) | P = 0.268 | |
| 0.512Hazard ratio (log scale) |
NACE, major adverse cardiac and cerebral events (MACCE) and BARC 2, 3 or 5 bleeding during routine care period · 12 to 15 months
- BARC 2, 3 or 5 bleeding did not differ during the routine care period
- Treatment effects during routine care consistent with those within 12 months after PCI
Use of intensified APT · 15 months
- Prior allocation to standard APT associated with greater use of intensified APT
Original publication
Abbreviated or Standard Antiplatelet Therapy in HBR Patients: Final 15-Month Results of the MASTER-DAPT Trial. JACC Cardiovasc Interv. Published 10 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →