Cardiometabolic & kidneyCohort study
Abdominal adiposity and accelerated biological ageing in relation to general and cardiovascular ageing in Chinese adults
- prospective China Kadoorie Biobank; observational study and Mendelian randomisation
- mediation analyses
Authors' conclusion
Abdominal adiposity is associated with ageing acceleration across multiple biological domains, especially via metabolic alterations captured by MetaboAge. Our findings demonstrated that targeting abdominal adiposity-related metabolic dysfunction may mitigate age-related conditions.
Study context
- Population
- Chinese adults in the China Kadoorie BiobankBiological age (BA) measures constructed in subsets · MetaboAge 4,391 · KDM-BA 12,369 · DNAm PhenoAge 980
- Exposure
- Abdominal adiposity (waist-to-hip ratio (WHR) and WHR adjusted for body mass index (WHRadjBMI)) in relation to BA acceleration, cardiovascular ageing and general ageing
Main finding
As reported in the abstract
AUROC difference, MetaboAge
0.040
AUROC difference, KDM-BA
0.012
p
p<0.001
Observational data: associations, not effects.
Further findings
Abdominal adiposity and BA acceleration (observational)
- WHR and KDM-BA acceleration (lowest estimate)
- 0.055 (95% CI 0.038 to 0.073)
- WHRadjBMI and DNAm PhenoAge acceleration (highest estimate)
- 0.107 (0.044 to 0.170)
- associations remained significant in Mendelian randomisation analyses
Mediation of abdominal adiposity effects on cardiovascular ageing by MetaboAge and KDM-BA acceleration
- %mediated
- 6.0%-25.3%
Mediation of associations with all-cause mortality by all three BA clocks accelerations
- %mediated
- 17.6%-60.6%
- MetaboAge contributing the largest proportion of mediation
Mediation of association between abdominal adiposity and frailty index
- KDM-BA acceleration mediated the association
Original publication
Summarised from the published abstract; every number is checked against it