Heart failure & cardiomyopathiesCohort study
Ablation for atrial fibrillation improves the outcomes in patients with heart failure with preserved ejection fraction
- Cohort study
- propensity-score matched
Authors' conclusion
Among patients with HFpEF and AF, the strategy of AF ablation to maintain SR was associated with a lower risk of the composite outcome of all-cause death or rehospitalization for worsening heart failure.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF)
- Participants
- 1,034 patients
- Exposure
- AF ablation vs medical therapy only
- Ablationn = 392
- No ablationn = 642reference
- Outcome
- Composite of:
- All-cause death
- Rehospitalization for worsening HF
- Follow-up
- Median 39 months
Main finding
As reported in the abstract
Adjusted hazard ratio
0.55
95% CI 0.37–0.82
P = 0.003
Ablation vs No ablation
adjusted HR 0.55 (95% CI 0.37–0.82); P = 0.003
Observational data: associations, not effects.
Secondary outcomes
| Outcome | adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Rehospitalization for worsening HF | 0.52 (0.34–0.80) | P = 0.003 | |
| Atrial tachycardia/AF recurrence · 33% relative decrease | 0.67 (0.54–0.84) | P < 0.001 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Ablation for atrial fibrillation improves the outcomes in patients with heart failure with preserved ejection fraction. Europace. Published 14 December 2023. doi:10.1093/europace/euad363
Summarised from the published abstract; every number is checked against it