Arrhythmias & electrophysiologyRandomised controlled trial
Ablation Strategies for Repeat Procedures in Atrial Fibrillation Recurrences Despite Durable Pulmonary Vein Isolation: The Prospective Randomized ASTRO AF Multicenter Trial
- Randomised controlled trial
- multicentre
- 7 centres
- planned interim analysis
- halted for futility
Authors' conclusion
The current study did not detect superiority of cryoballoon-guided LAAI over low-voltage area ablation in patients with atrial fibrillation despite durable PVI.
Study context
- Population
- Patients with AF despite durable pulmonary vein isolation
- Participants
- 82 vs 79
- Comparison
- Cryoballoon left atrial appendage isolation (LAAI) vs low-voltage area ablation
- LAAIn = 82
- Low-voltage arean = 79reference
- Primary endpoint
- Freedom from atrial tachyarrhythmias
- Follow-up
- Between 91 and 365 days after index ablation
Primary result
As reported in the abstract
Freedom from atrial tachyarrhythmias (Kaplan-Meier point estimate) · 91–365 days after index ablation
P = 0.8069
Further findings
- LAA isolation and closure (LAAI)
- 77 of 82 · LAA successfully isolated · Subsequent LAA closure 57 patients
Safety
Procedure-related complications
P = 0.10
- Procedure-related complications: group A = low-voltage area ablation; group B = cryoballoon-guided LAAI
Original publication
Ablation Strategies for Repeat Procedures in Atrial Fibrillation Recurrences Despite Durable Pulmonary Vein Isolation: The Prospective Randomized ASTRO AF Multicenter Trial. Circulation. Published 7 October 2024. doi:10.1161/circulationaha.124.069993
Summarised from the published abstract; every number is checked against it