Cardiometabolic & kidneyCohort study
Abnormal myocardial perfusion reserve and myocardial infarction determine cardiovascular outcomes in type 2 diabetes mellitus
- retrospective multicentre cohort
Authors' conclusion
In T2DM, abnormal MPR or MI are associated with MACCE, and the presence of both offers incremental prognostic value.
Study context
- Population
- Individuals with T2DM and healthy controls who underwent quantitative stress myocardial perfusion cardiovascular magnetic resonance (CMR) and late gadolinium enhancement (LGE)individuals with T2DM and healthy controls
- Participants
- 572 individuals
- Exposure
- Associations between myocardial perfusion reserve (MPR) and myocardial infarction (MI) with major adverse cardiovascular and cerebrovascular events (MACCE)
Main finding
As reported in the abstract
MACCE:
- Composite of all-cause death
- MI
- Stroke
- Heart failure hospitalization
- Late coronary revascularization>90 days after the CMR scan
Each group vs MI- and normal MPRAdjusted hazard ratio (95% CI)P value
MI+ or abnormal MPR
1.86(1.06–3.25)
P = 0.03MI+ and abnormal MPR
3.24(1.75–6.01)
P < 0.001- participants with at least one MACCE
- 81 participants (14%)
- deaths
- 25 (4%)
Observational data: associations, not effects.
Original publication
Abnormal myocardial perfusion reserve and myocardial infarction determine cardiovascular outcomes in type 2 diabetes mellitus. Eur Heart J Cardiovasc Imaging. Published 25 February 2026. doi:10.1093/ehjci/jeag047
Summarised from the published abstract; every number is checked against it