Coronary disease & ACSRandomised controlled trial
Accelerated Rule-Out of acute Myocardial Infarction using prehospital copeptin and in-hospital troponin: The AROMI study
- Randomised controlled trial
- non-inferiority
Authors' conclusion
Accelerated dual marker rule-out of AMI, using a combination of prehospital copeptin and first in-hospital high-sensitivity troponin T, reduces length of hospital stay without increasing the rate of 30-day major adverse cardiac events as compared to using a 0 h/3 h rule-out strategy.
Study context
- Population
- Patients with suspected acute MI transported to hospital by ambulance
- Participants
- 4,351 patients
- Comparison
- Accelerated dual-marker rule-out vs standard 0 h/3 h rule-out
- Primary endpoint
- Length of stay in patients discharged after early rule-out of acute MI
Primary result
As reported in the abstract
Length of stay (patients discharged after rule-out)
Mean reduction
0.9 h
95% CI 0.7–1.1
Accelerated rule-out vs Standard rule-out
mean reduction 0.9 h (95% CI 0.7–1.1)
Safety
| Outcome | absolute risk difference (95% CI) | P value | |
|---|---|---|---|
| MACE · 30 days · non-inferior · non-inferiority | −0.4% (−2.5 to 1.7) | P for non-inferiority = 0.013 | |
| −3−2−1012Difference (linear scale) |
Original publication
Accelerated Rule-Out of acute Myocardial Infarction using prehospital copeptin and in-hospital troponin: The AROMI study. Eur Heart J. Published 21 July 2023. doi:10.1093/eurheartj/ehad447
Summarised from the published abstract; every number is checked against it