Pulmonary vascular disease & thromboembolismCohort study
Accelerometer-measured intensity-specific physical activity, genetic predisposition, and the risk of venous thromboembolism: a cohort study
- Prospective cohort study
Authors' conclusion
Higher levels of physical activity of any intensity were associated with a lower risk of new-onset VTE. However, the negative association between moderate-to-vigorous-intensity physical activity and new-onset VTE was significant only in participants with low and intermediate genetic predispositions to VTE.
Study context
- Population
- UK Biobank participants with accelerometer-measured physical activity, accounting for genetic risk (venous thromboembolism (VTE) polygenic risk score (PRS))1,182 incident VTE cases
- Participants
- 85,116 participants
- Exposure
- Highest vs lowest level of accelerometer-measured physical activity
- Outcome
- Incident VTE (linked hospital records and death registries)
- Follow-up
- Median 6.18 years
Main finding
As reported in the abstract
Incident VTE
Highest level vs Lowest levelHazard ratio (95% CI)
total volume of physical activity; adjusted
0.60(0.45–0.79)
moderate-to-vigorous-intensity physical activity; adjusted
0.66(0.51–0.86)
light-intensity physical activity; adjusted
0.66(0.51–0.85)
Observational data: associations, not effects.
Further findings
VTE by genetic risk (PRS) subgroup
- Total and light-intensity physical activity negatively associated with VTE risk in low, intermediate and high PRS
- Moderate-to-vigorous-intensity physical activity protective only in low and intermediate PRS
- P for interaction = 0.02
Original publication
Accelerometer-measured intensity-specific physical activity, genetic predisposition, and the risk of venous thromboembolism: a cohort study. Eur J Prev Cardiol. Published 19 August 2024. doi:10.1093/eurjpc/zwae273
Summarised from the published abstract; every number is checked against it