Heart failure & cardiomyopathies
Accelerometer-measured physical activity in patients with heart failure and reduced ejection fraction: Determinants and relationship with patient-reported health status
Authors' conclusion
In patients with HFrEF, older age and anemia were independently associated with lower activity. Moreover, physical activity only weakly increased with better health status, suggesting that changes in physical activity reflect improvements in patients' health status to a limited degree.
Study context
- Population
- Outpatients with HF with reduced ejection fraction (HFrEF)180 (95%) with complete data
- Primary endpoint
- Determinants of accelerometer-measured physical activity (average counts per minute, CPM) and its relationship with KCCQ health status
Primary result
As reported in the abstract
Baseline median physical activity, counts per minute (CPM) (Q1-Q3 1,111-1,585)
1,318
Age, β per year increase, CPM (95% CI −16 to −5.1), P = .00015
−10
Anemia, β, CPM (95% CI −9.1 to −244), P = .035
−126
All Kansas City Cardiomyopathy Questionnaire (KCCQ) summary scores independently associated with activity, β point estimates CPM (all P < .02)
3.7, 4.6, and 4.9
Further findings
12-week change in KCCQ-CSS and activity level
- Mean increase in CPM per 5-point increase in KCCQ-CSS (95% CI 1.5 to 34.0), P = 0.032; only KCCQ-CSS associated
- 17.5
- Associations not modified by treatment allocation (interaction P-values > .05)
Original publication
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