Heart failure & cardiomyopathiesCohort study
Accelerometer-Measured Physical Activity, Sedentary Time, and Heart Failure Risk in Women Aged 63 to 99 Years
- Prospective cohort study
Authors' conclusion
Higher accelerometer-measured PA (MVPA, light PA, steps per day) was associated with lower risk (and greater total sedentary time with higher risk) of overall HF and HFpEF in a racially and ethnically diverse cohort of older women.
Study context
- Population
- Women aged 63 to 99 years without known heart failure (HF) (OPACH study), accelerometry 2012–2014, follow-up through February 2022407 HF cases
- Participants
- 5,951 women
- Exposure
- Accelerometer-measured physical activity (PA) and sedentary time
- Outcome
- Adjudicated incident HF, HFpEF and HFrEF
- Follow-up
- Mean (SD) 7.5 (2.6) years
Main finding
As reported in the abstract
Incident HF, HFpEF and HFrEF per 1-SD increment (fully adjusted) · mean (SD) 7.5 (2.6) years follow-up
Hazard ratio (95% CI)
minutes per day total PAoverall HF, per 1-SD increment
0.85(0.75–0.95)
minutes per day total PAHFpEF, per 1-SD increment
0.78(0.67–0.91)
minutes per day total PAHFrEF, per 1-SD increment
1.02(0.81–1.28)
steps per dayoverall HF, per 1-SD increment
0.74(0.63–0.88)
steps per dayHFpEF, per 1-SD increment
0.71(0.57–0.88)
steps per dayHFrEF, per 1-SD increment
0.83(0.62–1.12)
minutes per day total sedentaryoverall HF, per 1-SD increment
1.17(1.04–1.33)
minutes per day total sedentaryHFpEF, per 1-SD increment
1.29(1.10–1.51)
minutes per day total sedentaryHFrEF, per 1-SD increment
0.94(0.75–1.18)
Each row per its own increment, as printed
Observational data: associations, not effects.
Further findings
Subgroups by age, race and ethnicity, BMI, physical function, comorbidity score
- Associations did not meaningfully differ
Sedentary bout duration
- Results inconsistent
Original publication
Accelerometer-Measured Physical Activity, Sedentary Time, and Heart Failure Risk in Women Aged 63 to 99 Years. JAMA Cardiol. Published 1 April 2024. doi:10.1001/jamacardio.2023.5692
Summarised from the published abstract; every number is checked against it