Prevention & lipidsCohort study
Accelerometer-Measured Sedentary Behavior and Risk of Future Cardiovascular Disease
- Prospective cohort study
- UK Biobank
- accelerometer-measured exposure
Authors' conclusion
Sedentary behavior is broadly associated with future adverse CV outcomes, with particularly prominent effects on HF and CV mortality, where risk inflected at approximately 10.6 h/d.
Study context
- Population
- UK Biobank participants undergoing 1 week of accelerometry (age 62 ± 8 years, 56.4% women)
- Participants
- 89,530 participants
- Exposure
- Sedentary time quartiles
- Outcome
- Incident atrial fibrillation (AF), myocardial infarction (MI), HF and CV mortality
Main finding
As reported in the abstract
Each group vs second quartileHazard ratio (95% CI)
Top quartileHF
1.45(1.28–1.65)
Top quartileCV mortality
1.62(1.34–1.96)
Higher sedentary timeincident AF; approximately linear relation
1.11(1.01–1.21)
Higher sedentary timeMI; approximately linear relation
1.15(1.00–1.32)
- Median sedentary time
- 9.4 h/d (Q1-Q3: 8.2-10.6)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| HF with 30-minute decrease in sedentary time (reallocation, >10.6 h/d) — 30-minute decrease in sedentary time vs Second quartile · all with >10.6 h/d · compositional analysis | 0.93 (0.90–0.96) | |
| HF with 30-minute decrease in sedentary time (reallocation, >10.6 h/d) — 30-minute decrease in sedentary time vs Second quartile · those meeting guideline MVPA · compositional analysis | 0.93 (0.87–0.99) | |
| 0.512Hazard ratio (log scale) |
Heart failure (HF) and cardiovascular (CV) mortality among those meeting guideline moderate to vigorous physical activity (MVPA) (≥150 min/wk) (subgroup)
- Associations with HF and CV mortality persisted
Original publication
Accelerometer-Measured Sedentary Behavior and Risk of Future Cardiovascular Disease. J Am Coll Cardiol. Published 15 November 2024. doi:10.1016/j.jacc.2024.10.065
Summarised from the published abstract; every number is checked against it