Heart failure & cardiomyopathies
Accurate diagnosis of apical hypertrophic cardiomyopathy using explainable advanced electrocardiogram analysis
Authors' conclusion
Explainable A-ECG has excellent diagnostic accuracy for ApHCM, even when the hypertrophy is relative, with A-ECG analysis providing incremental diagnostic value over imaging alone.
Study context
- Population
- Patients with apical hypertrophic cardiomyopathy (ApHCM) and comparator subjects with standard resting 12-lead electrocardiogram (ECGs)92 ApHCM underwent CMR
- Comparison
- Explainable advanced ECG for diagnosis of ApHCM vs comparator subjects
- Comparatorn = 2,449reference
- Outcome
- Diagnostic accuracy (AUC) of A-ECG for ApHCM
Performance
As reported in the abstract
Discrimination of ApHCM from other diseases
Multivariable logistic regression, 4 advanced ECG (A-ECG) measures: AUC
0.982
bootstrapped 95% CI 0.965–0.993
Linear discriminant analysis: AUC (0.986-0.991)
0.989
Original publication
Accurate diagnosis of apical hypertrophic cardiomyopathy using explainable advanced electrocardiogram analysis. Europace. Published 8 April 2024. doi:10.
Summarised from the published abstract; every number is checked against it