HypertensionSecondary analysis
Achieved systolic blood pressure and cardiovascular outcomes in 60–80-year-old patients: the Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial
- Secondary analysis of the STEP randomised trial
- multicentre
Authors' conclusion
Maintaining SBP at <130 mmHg offers additional cardiovascular benefits among young-older patients with hypertension.
Study context
- Population
- Hypertensive patients aged 60–80 years without prior strokeenrolled in STEP
- Participants
- 8,511 patients
- Comparison
- Target-achieved intensive vs target-achieved standard treatment
- Target-achieved (TA) intensiven = 3,053
- TA standardn = 3,427reference
- Primary endpoint
- CV events
- Follow-up
- median 3.38-year follow-up
Primary result
As reported in the abstract
Adjusted hazard ratio
0.61
95% CI 0.46–0.80
P < 0.001
By group
TA intensive vs TA standard
adjusted HR 0.61 (95% CI 0.46–0.80); P < 0.001
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| CV events, intensive treatment: target not achieved vs TA | 2.04 (1.44–2.88) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Mean achieved systolic blood pressure (SBP) and CV events (cubic spline)
- J-shaped relationship; lowest risk at SBP (mmHg)
- 126.9
Original publication
Achieved systolic blood pressure and cardiovascular outcomes in 60–80-year-old patients: the Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial. Eur J Prev Cardiol. Published 12 May 2023. doi:10.1093/eurjpc/zwad142
Summarised from the published abstract; every number is checked against it