Coronary disease & ACSRandomised controlled trial
Acoustic-based rule-out of stable coronary artery disease: the FILTER-SCAD trial
- Randomised controlled trial
- multicentre
- 6 Danish and Swedish outpatient clinics
- Randomized October 2019 to September 2022
Authors' conclusion
The implementation strategy of providing cardiologists with a CAD-score alongside SDE did not reduce testing overall but indicated a possible role in patients with low CCS likelihood.
Study context
- Population
- Outpatients with suspected new-onset chronic coronary syndrome
- Participants
- 2,008 outpatients
- Comparison
- Standard diagnostic examination (SDE) plus coronary artery disease (CAD)-score vs SDE with pre-test probability (PTP)
- CAD-scoren = 1,002
- Primary endpoint
- Cumulative number of diagnostic tests
- Follow-up
- One year
Primary result
As reported in the abstract
Testing deferred overall
22%
Further findings
Deferred testing, PTP ≤ 5% subgroup
- Proportion with deferred testing increased from 28% to 52%
- P < 0.001
Angina-related health status, quality of life
- No differences
Safety
Major adverse cardiac events (MACE) (key safety endpoint)
- Overall MACE
- 2.4 per 100 person-years
- Absolute risk difference
- 0.49% (95% CI −1.96-0.97)
- Non-inferiority regarding safety established
- P for non-inferiority = .003
Original publication
Acoustic-based rule-out of stable coronary artery disease: the FILTER-SCAD trial. Eur Heart J. Published 1 September 2024. doi:10.1093/eurheartj/ehae570
Summarised from the published abstract; every number is checked against it