Arrhythmias & electrophysiologyRandomised controlled trial
Acute durability of cavotricuspid isthmus block after pulsed electric field ablation: randomized comparison of two pentaspline catheter configurations (SECTION trial)
- Randomised controlled trial
Authors' conclusion
Pulsed electric field ablation of the CTI using the flower configuration of the pentaspline catheter demonstrated higher acute efficacy in achieving CTI block and a more favourable safety profile regarding haemolysis compared to the basket configuration.
Study context
- Population
- Patients undergoing pulsed electric field (PEF) ablation of the cavotricuspid isthmus (CTI) in conjunction with AF ablation
- Participants
- 178 patients
- Comparison
- Flower vs Basket
- Flowern = 83
- Basketn = 95reference
- Primary endpoint
- Acute efficacy of CTI ablation (acute CTI block durability) and extent of haemolysis
Primary result
Acute reconduction
Hazard ratio
0.14
95% CI 0.06–0.40
P < 0.001
By group
Flower vs Basket
HR 0.14 (95% CI 0.06–0.40); P < 0.001
As reported in the abstract
Further findings
Time to CTI block
P < 0.001
| Outcome | Flower | Basket | P value |
|---|---|---|---|
| Applications required to achieve CTI block | 3.4 ± 3.1 | 8.0 ± 4.1 | P < 0.001 |
| Total applications | 10.1 ± 3.4 | 13.3 ± 5.1 | P < 0.001 |
Safety
Haemolysis: post-procedural free haemoglobin · immediately after CTI ablation
P < 0.001
| Outcome | Flower | Basket | P value |
|---|---|---|---|
| Transient ST elevations · without clinical consequence | 1 events | Not reported in the abstract |
Original publication
Acute durability of cavotricuspid isthmus block after pulsed electric field ablation: randomized comparison of two pentaspline catheter configurations (SECTION trial). Europace. Published 23 September 2025. doi:10.1093/europace/euaf234
Summarised from the published abstract; every number is checked against it