Arrhythmias & electrophysiologyRandomised controlled trial
Acute Effects of Cannabis Inhalation on Cardiac Ectopy, Physical Activity, Sleep, and Glucose
- Randomised crossover trial
- prospective
- pragmatic
Randomisation adherence imperfect but generally supportive of assignment adherence
Authors' conclusion
In a pragmatic crossover design including habitual cannabis users, randomization to inhaled cannabis was associated with less cardiac ectopy, driven by fewer premature atrial contractions.
Study context
- Population
- Adults who regularly smoked or vaped cannabis, without a history of cardiac arrhythmias713 cannabis days · 616 abstinence days
- Participants
- 108 adults
- Comparison
- Inhaled cannabis vs abstinence
- Primary endpoint
- Daily cardiac ectopy (daily premature atrial and premature ventricular contractions)
- Follow-up
- 14 days
Primary result
Ectopic beats
Relative risk
0.91
95% CI 0.85–0.98
P = 0.02
Inhaled cannabis vs Abstinence
RR 0.91 (95% CI 0.85–0.98); P = 0.02
As reported in the abstract
Further findings
Daily premature atrial contractions
- Decreased by 10% with inhaled cannabis: RR 0.90, 95% CI 0.82-0.97
- P = 0.012
Premature ventricular contractions
- No significant change
Ectopic beats per cannabis inhalation
- 2% reduction per inhalation: RR 0.98, 95% CI 0.97-0.99
- P = 0.043
Step counts, sleep duration, glucose levels
- No significant differences
Original publication
Acute Effects of Cannabis Inhalation on Cardiac Ectopy, Physical Activity, Sleep, and Glucose. J Am Coll Cardiol. Published 30 July 2026. doi:10.1016/j.jacc.2026.07.014
Summarised from the published abstract; every number is checked against it