Coronary disease & ACSMeta-analysis
Acute myocardial infarction triggered by physical exertion: a systematic review and meta-analysis
- Systematic review and meta-analysis of case-crossover studies
- random-effects model
- meta-regression
Authors' conclusion
Every tenth AMI may be assigned to physical exertion. The impact was more pronounced among younger patients, those exposed to exertion one to three times a week, and those not taking β-blockers.
Study context
- Population
- Patients with acute MI
- Participants
- 19,891 patients · 12 studies
- Comparison
- Episodic physical exertion vs control periods
- Outcome
- RR of exertion-related acute MI and population attributable fraction (PAF)
Pooled result
Exertion-related acute MI
Relative risk
3.46
95% CI 3.16–3.78
Physical exertion vs Control periods
RR 3.46 (95% CI 3.16–3.78)
As reported in the abstract
- Total population attributable fraction (PAF)
- 10.6% (95% CI, 9.44-11.83)
Further pooled results
Modifiers of exertion-related acute MI (meta-regression)
- Per additional year of age: RR increased
- ∼3%
- Per additional year of age: PAF decreased
- 2%
- Per additional time of habitual activity per week: RR decreased
- ∼43%
- Impact greater with exertion one to three times a week
- ≥20% of cases
- Impact greater without vs with β-blockers
- P = 0.049
Original publication
Acute myocardial infarction triggered by physical exertion: a systematic review and meta-analysis. Eur J Prev Cardiol. Published 15 February 2023. doi:10.1093/eurjpc/zwad045
Summarised from the published abstract; every number is checked against it