Acute cardiac care & resuscitationMeta-analysis
Acute myocardial infarction vs acute decompensated heart failure in cardiogenic shock: a systematic review and meta-analysis of clinical phenotypes and mortality
- Systematic review and meta-analysis of observational studies
- random-effects (REML with Hartung-Knapp)
- PRISMA 2020
Phenotype-defining variables (LVEF, SCAI stage, invasive haemodynamics) extractable in <1.1% of pooled cohort
Authors' conclusion
AMI-CS presents more fulminantly than ADHF-CS, with markedly greater mechanical support use and higher short-term mortality.
Study context
- Population
- Patients with cardiogenic shock, observational studies 2019–2025
- Participants
- 497,368 patients · 29 studies
- Comparison
- AMI-CS vs ADHF-CS
- Outcome
- Short-term (in-hospital/30-day) mortality
- Follow-up
- in-hospital/30-day
Pooled result
Short-term mortality
Odds ratio
1.58
95% CI 1.06–2.37
AMI-CS vs ADHF-CS
OR 1.58 (95% CI 1.06–2.37)
As reported in the abstract
Further pooled results
| Outcome | MD (years) (95% CI) | |
|---|---|---|
| Age · older in AMI-CS | 4.76 (0.37–9.14) | |
| −50510Difference, years (linear scale) |
| Outcome | MD (%) (CI) | |
|---|---|---|
| EF at presentation · higher in AMI-CS | 6.04 (4.53–7.55) | |
| −50510Difference, % (linear scale) |
| Outcome | OR (CI) | |
|---|---|---|
| Cardiac arrest | 2.03 (1.04–3.98) | |
| SCAI stage D/E shock | 1.50 (1.33–1.70) | |
| Temporary mechanical circulatory support — AMI-CS vs ADHF-CS · any device | 5.44 (2.83–10.46) | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | OR |
|---|---|
| Temporary mechanical circulatory support — AMI-CS vs ADHF-CS · IABP | 4.73 |
| Temporary mechanical circulatory support — AMI-CS vs ADHF-CS · pVAD | 2.67 |
| Temporary mechanical circulatory support — AMI-CS vs ADHF-CS · VA-ECMO | 3.27 |
Invasive filling pressures
- Invasive filling pressures did not differ
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Acute myocardial infarction vs acute decompensated heart failure in cardiogenic shock: a systematic review and meta-analysis of clinical phenotypes and mortality. Eur J Heart Fail. Published 9 June 2026. doi:10.1093/ejhf/xuag186
Summarised from the published abstract; every number is checked against it