Heart failure & cardiomyopathies
Acyl Ghrelin Increases Cardiac Output While Preserving Right Ventricular-Pulmonary Arterial Coupling in Heart Failure
Authors' conclusion
Treatment with acyl ghrelin increases CO while preserving or even improving RVPAC in HFrEF, possibly due to increased contractility, reduced PVR and/or reduced left sided filling pressures.
Study context
- Population
- Patients with heart failure with reduced ejection fraction (HFrEF)22 with available right ventricular-pulmonary arterial coupling (RVPAC)
- Participants
- 30 patients
- Comparison
- Acyl ghrelin vs placebo
- Acyl ghrelinn = 12
- Placebon = 10reference
- Primary endpoint
- RV-pulmonary arterial coupling (RVPAC), assessed echocardiographically
- Follow-up
- 120 min
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
RVPAC · baseline to 120 min
| Group | Baseline | 120 min | Within-group P |
|---|---|---|---|
| Acyl ghrelin | 5.9 (5.3-7.6) | 6.3 (4.8-7.5) | P = 0.372 |
| Placebo | 5.2 (4.3-6.4) | 4.8 (4.2-5.8) | P = 0.035 |
Baseline
Acyl ghrelin5.9 (5.3-7.6)
Placebo5.2 (4.3-6.4)
120 min
Acyl ghrelin6.3 (4.8-7.5)
Placebo4.8 (4.2-5.8)
Within-group P
Acyl ghrelinP = 0.372
PlaceboP = 0.035
Further findings
| Outcome | Acyl ghrelin | P value |
|---|---|---|
| Cardiac output · baseline to 120 minCO increased with acyl ghrelin vs placebo | P = 0.036 | |
| Baseline | 4.0 (3.5-4.6) | |
| 120 min | 4.6 (3.9-6.1) | |
| Increase | 15% | |
| Within-group P | P = 0.003 |
RV pressure gradient
- Change between groups: unchanged
Original publication
Acyl Ghrelin Increases Cardiac Output While Preserving Right Ventricular-Pulmonary Arterial Coupling in Heart Failure. ESC Heart Fail. Published 29 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →