Arrhythmias & electrophysiologyRandomised controlled trial
Additional Lesion Sets in Ablation of Outflow Tract Premature Ventricular Contractions
- Randomised controlled trial
- multicentre
- prospective
- 18 hospitals in China
Authors' conclusion
This randomized clinical trial showed a benefit of additional ablation in reducing the recurrence of OT-PVCs compared with the single-point ablation strategy, without increased complication risk.
Study context
- Population
- Patients receiving their first catheter ablation for outflow tract PVCs, China, 2021–2023308 enrolled
- Participants
- 286 patients
- Comparison
- Additional ablation vs Control
- Primary endpoint
- Freedom from PVC recurrence (≥80% reduction of PVC burden)
- Follow-up
- 3 months postprocedure
Primary result
As reported in the abstract
Freedom from PVCs · median follow-up 3.2 months
P < 0.001
Further findings
Mean
| Outcome | Additional ablation | Control | P value |
|---|---|---|---|
| Reduction in PVC burden | 23.0% (SD 10.5%) | 19.0% (SD 10.4%) | P = 0.002 |
Safety
Severe periprocedural complications
- No severe periprocedural complications in either group
Original publication
Additional Lesion Sets in Ablation of Outflow Tract Premature Ventricular Contractions. JAMA Cardiol. Published 1 November 2024. doi:10.1001/jamacardio.2024.2975
Summarised from the published abstract; every number is checked against it