Valvular & structural heart diseaseCohort study
Additive Prognostic Value of Left Ventricular Dispersion and Deformation in Patients With Severe Aortic Stenosis
- Prospective cohort study
Authors' conclusion
LV-MD is a reproducible parameter independently associated with an increased risk of mortality in SAS. Increased LV-MD associated with depressed LV-GLS identifies a subgroup of patients with an increased mortality risk.
Study context
- Population
- Severe aortic stenosis (AVA indexed ≤0.6 cm²/m² and/or AVA ≤1 cm²), LVEF ≥50%, no or mild symptoms149 died
- Participants
- 364 participants
- Exposure
- Left ventricular-mechanical dispersion (LV-MD) ≥68 ms vs <68 ms; combined with LV-GLS ≥−15%
- Outcome
- Overall mortality
- Follow-up
- Median 41 months
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)P value
LV-MD ≥68 ms vs LV-MD <68 ms
1.41(1.01–1.96)
P = 0.044Both criteria vs None or one criterion
2.02(1.34–3.03)
P = 0.001Observational data: associations, not effects.
Further findings
Interobserver reproducibility of LV-MD
- Intraclass correlation coefficient
- 0.90 (95% CI: 0.72-0.97)
Original publication
Additive Prognostic Value of Left Ventricular Dispersion and Deformation in Patients With Severe Aortic Stenosis. JACC Cardiovasc Imaging. Published 8 November 2023. doi:10.1016/j.jcmg.2023.09.010
Summarised from the published abstract; every number is checked against it