Prevention & lipidsMeta-analysis
Adherence to Continuous Positive Airway Pressure (CPAP) Treatment and the Risk of Recurrent Cardiovascular Events
- Systematic review and individual participant data meta-analysis of randomised trials
- one-stage and 2-stage individual participant data (IPD) meta-analyses
- mixed-effect Cox regression
Mean [SD] follow-up 3.25 [1.8] years; mean [SD] CPAP adherence 3.1 {2.4} h/day
Authors' conclusion
Adherence to CPAP was associated with a reduced MACCE recurrence risk, suggesting that treatment adherence is a key factor in secondary cardiovascular prevention in patients with OSA.
Study context
- Population
- Adults with CVD and obstructive sleep apnea (OSA) (secondary prevention)IPD meta-analysis of SAVE, ISAACC, RICCADSA
- Participants
- 4,186 adults
- Comparison
- CPAP vs no CPAP
- Outcome
- First recurrent MACCE
Pooled result
As reported in the abstract
Hazard ratio
1.01
95% CI 0.87–1.17
CPAP vs No CPAP
HR 1.01 (95% CI 0.87–1.17)
Further pooled results
| Outcome | HR (95% CI) | |
|---|---|---|
| MACCE with good adherence to CPAP (≥4 h/day) · on-treatment analysis | 0.69 (0.52–0.92) | |
| 0.512Hazard ratio (log scale) |
- MACCE with good adherence to CPAP (≥4 h/day): marginal structural Cox models with inverse probability of treatment weighting
Original publication
Adherence to CPAP Treatment and the Risk of Recurrent Cardiovascular Events. JAMA. Published 3 October 2023. doi:10.1001/jama.2023.17465
Summarised from the published abstract; every number is checked against it