Adherence to perindopril/amlodipine/atorvastatin combination according to the administration strategy
Authors' conclusion
In a real-life setting, the polypill improved treatment adherence and reduced healthcare costs compared to the corresponding separate-pill combination.
Study context
- Population
- Patients prescribed perindopril/amlodipine/atorvastatin, Lombardy (Italy) healthcare utilization database, 2019–2021matched cohort
- Participants
- 1,110 vs 1,110
- Exposure
- Polypill vs separate-pill combination of perindopril/amlodipine/atorvastatin
- Polypilln = 1,110
- Separate-pill combinationn = 1,110reference
- Outcome
- Adherence as proportion of follow-up days covered (PDC); high adherence PDC >75%, low adherence PDC <25%
- Follow-up
- Year after first dispensation
Methodological detailsmatched, healthcare utilization database, group-based trajectory modelling
- Matched
- Healthcare utilization database
- Group-based trajectory modelling
Main finding
As reported in the abstract
Adherence (PDC) · 1 year
Polypill
- High adherence
- 60%
- Low adherence
- 5%
Separate-pill combination
- High adherence
- 18%
- Low adherence
- 37%
High adherence
Polypill60%
Separate-pill combination18%
Low adherence
Polypill5%
Separate-pill combination37%
Polypill vs Separate-pill combinationRelative risk (95% CI)
High adherence
3.29(2.88–3.75)
Low adherence
0.13(0.10–0.18)
Observational data: associations, not effects.
Further findings
| Outcome | Polypill | Separate-pill combination | P value |
|---|---|---|---|
| CV-related healthcare costs | €676 | €1068 | P = 0.003 |
Original publication
Adherence to perindopril/amlodipine/atorvastatin combination according to the administration strategy. Eur Heart J Qual Care Clin Outcomes. Published 6 January 2025. doi:10.
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