Heart failure & cardiomyopathies
Adipokine profile in acute heart failure: associations with natriuretic response and prognosis
- prospective observational study
- consecutive acute HF (AHF) patients
+1 more
- consecutive acute HF (AHF) patients
Authors' conclusion
In AHF, individual adipokines are modestly associated with the early natriuretic response, whereas an integrated adipose-inflammatory profile shows a more consistent association with sodium excretion and adverse outcomes. These findings suggest that adipokine signalling may reflect biological pathways associated with diuretic response and prognosis, though the results should be considered hypothesis-generating.
Study context
- Population
- Patients with acute heart failure (AHF)
- Participants
- 262 consecutive AHF patients
- Exposure
- Associations between circulating adipokine profiles, early natriuretic response (post-diuretic spot urine sodium 2 h after intravenous loop diuretic), and clinical outcomes
Main finding
As reported in the abstract
Domain-3 adipokines in patients with impaired natriuretic response (uNa+ < 90 mmol/L)
- Higher levels of selected Domain-3 adipokines, including chemerin and FABP4
Observational data: associations, not effects.
Further findings
| Outcome | β (95% CI) | P value |
|---|---|---|
| Adipokine score and uNa+ · after multivariable adjustment · multivariable adjustment | 3.37 (1.51–5.23) | P < 0.001 |
Individual adipokines and early natriuretic response · 2 h after intravenous loop diuretic
- Individual adipokines showed modest associations with early natriuretic response
- Visfatin significantly associated with lower post-diuretic uNa+
- IL-6, FABP4, and Adipsin demonstrated directional but non-significant trends
All-cause mortality · 1-year follow-up
- IL-6, resistin, and FABP4 were independently associated with mortality
- FABP4 consistently demonstrated associations with both impaired natriuresis and adverse outcomes
Original publication
Adipokine profile in acute heart failure: associations with natriuretic response and prognosis. ESC Heart Fail. Published 26 May 2026. doi:10.1093/eschf/xvag150
Summarised from the published abstract; every number is checked against it