Cardio-oncology & otherCohort study
Adiposity and Muscle Strength in Men With Prostate Cancer and Cardiovascular Outcomes
- Prospective cohort study
- international
Authors' conclusion
ADT was associated with increased adiposity and reduced strength over 12-month follow-up. High waist circumference and low baseline strength were associated with future adverse cardiovascular outcomes.
Study context
- Population
- Patients with prostate cancer diagnosed in the prior 12 months or treated with androgen deprivation therapy (ADT) for the first time1,731 (43.6%) exposed to ADT
- Participants
- 3,967 patients
- Exposure
- Measures of adiposity and strength and CV outcomes
- Outcome
- Cardiovascular outcomes (cardiovascular death, myocardial infarction, stroke, heart failure, arterial revascularization, peripheral arterial disease, and venous thromboembolism) in relation to measures of adiposity and strength
Main finding
As reported in the abstract
Future CV event (adjusted)
Hazard ratio (95% CI)P value
Waist circumference >110 cm
1.40(1.03–1.90)
P = 0.029Handgrip strength <29.5 kg
1.59(1.14–2.22)
P = 0.006Observational data: associations, not effects.
Secondary outcomes
Changes in physical measures with ADT · 12 months
- Weight increase
- 1.6%
- Waist circumference increase
- 2.2%
- Hip circumference increase
- 1.6%
- Waist-to-hip ratio increase
- 0.1%
- Handgrip strength reduction
- 27.4%
- Gait speed decrease
- 0.1%
Original publication
Adiposity and Muscle Strength in Men With Prostate Cancer and Cardiovascular Outcomes. JACC CardioOncol. Published 3 September 2024. doi:10.1016/j.jaccao.2024.07.011
Summarised from the published abstract; every number is checked against it