Valvular & structural heart disease
Advanced Imaging Assessment of the Impact of Tricuspid Regurgitation on Cardiac Remodeling: The TRILUMINATE Pivotal Imaging Substudy
Authors' conclusion
Advanced imaging from the TRILUMINATE Pivotal imaging substudy demonstrated that TriClip effectively reduced TR. Significant cardiac remodeling was observed at 30 days and sustained at 1 year. With TriClip, the extent of cardiac remodeling was associated with the degree of TR reduction.
Study context
- Population
- Symptomatic patients with severe tricuspid regurgitation (TR)
- Participants
- 69 patients
- Comparison
- TriClip vs medical therapy
- TriClipn = 31
- Controln = 38reference
- Primary endpoint
- Longitudinal changes in right heart remodeling by CMR and 4D-CT
- Follow-up
- 30 days and 1 year
Methodological detailsprospective imaging substudy, 10 sites, imaging core lab
- Prospective imaging substudy
- 10 sites
- Imaging core lab
Primary result
As reported in the abstract
Right heart remodeling · 30 days
- TR volume significantly decreased with TriClip (70% reduction)
- P < 0.0001
- Association between changes in TR volume and RV end-diastolic volume
- r = 0.90; P < 0.0001
- RV end-diastolic volume reduction with TriClip (12% reduction), sustained through 1 year
- P < 0.001
- Tricuspid annular area reduction with TriClip (11% reduction), sustained through 1 year
- P < 0.0001
Original publication
Advanced Imaging Assessment of the Impact of Tricuspid Regurgitation on Cardiac Remodeling: The TRILUMINATE Pivotal Imaging Substudy. J Am Coll Cardiol. Published 20 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →