Cardio-oncology & otherCohort study
Advanced maternal age at first delivery as a risk factor for long-term cardiovascular disease
- population-based retrospective cohort study
- tertiary medical centre
- 1991-2021
Authors' conclusion
AMA at first delivery is associated with increased long-term risk of cardiovascular morbidity. These results suggest the importance of tailored monitoring and preventive strategies for women of AMA at first delivery to potentially mitigate future cardiovascular risks.
Study context
- Population
- Primiparous women at a tertiary medical centre<30 years 43,426 · 30-34 years 2,807 · 35-40 years 658 · >40 years 155
- Participants
- 47,046 primiparous women
- Exposure
- association between advanced maternal age (AMA) at first delivery and maternal long-term cardiovascular disease (CVD)
- <30 yearsn = 43,426
- 30-34 yearsn = 2,807
- 35-40 yearsn = 658
- >40 yearsn = 155
Main finding
As reported in the abstract
Cumulative incidence of CVD
significant increase in the cumulative incidence of CVD associated with AMA, particularly among aged >40 years
Log Rank: P < 0.001
Observational data: associations, not effects.
Further findings
Long-term CVD
| Comparison | aHR (95% CI) | P value | |
|---|---|---|---|
| AMA · increased risk with AMA · Cox regression adjusting for confounders | 1.81 (1.41–2.68) | P < 0.001 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Hypertension, ischaemic heart disease, central vascular events, and peripheral vascular disease
- significantly more frequent in older age groups
Original publication
Advanced maternal age at first delivery as a risk factor for long-term cardiovascular disease. Eur Heart J Qual Care Clin Outcomes. Published 25 April 2026. doi:10.1093/ehjqcco/qcag076
Summarised from the published abstract; every number is checked against it