Cardiometabolic & kidneyCohort study
Adverse Cardiovascular Outcomes in Patients With Obstructive Sleep Apnea and Obesity
- Retrospective cohort study
- overlap-weighted
Authors' conclusion
Among patients with moderate-to-severe OSA and obesity, metabolic surgery, compared with nonsurgical management, was associated with a significantly lower risk of incident MACE and death.
Study context
- Population
- Adults with BMI 35 to 70 kg/m² and moderate-to-severe obstructive sleep apnea (OSA) at a US health system (2004–2018)median follow-up 5.3 years
- Participants
- 13,657 adults
- Exposure
- Metabolic surgery vs nonsurgical management
- Metabolic surgeryn = 970
- Nonsurgicaln = 12,687reference
- Outcome
- Incident major adverse cardiovascular events (MACE)
- Follow-up
- 10 years
Main finding
MACE, 10-year cumulative incidence
Adjusted hazard ratio
0.58
95% CI 0.48–0.71
P < 0.001
By group
Metabolic surgery vs Nonsurgical
adjusted HR 0.58 (95% CI 0.48–0.71); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Cumulative incidence
| Outcome | Metabolic surgery | Nonsurgical | adjusted HR (95% CI) | P value | |
|---|---|---|---|---|---|
| All-cause mortality · 10 years | 9.1% (95% CI 5.7%–12.4%) | 12.5% (95% CI 11.2%–13.8%) | 0.63 (0.45–0.89) | P = 0.009 | |
| 0.512Adjusted hazard ratio (log scale) |
Body weight · 10 years
- Mean between-group difference in body weight
- 26.6 kg (95% CI: 25.6-27.6 kg)
- Mean between-group difference in body weight, %
- 19.3% (95% CI: 18.6%-19.9%)
Original publication
Adverse Cardiovascular Outcomes in Patients With Obstructive Sleep Apnea and Obesity. J Am Coll Cardiol. Published 21 June 2024. doi:10.1016/j.jacc.2024.06.008
Summarised from the published abstract; every number is checked against it