Arrhythmias & electrophysiologyCohort study
Adverse pregnancy outcomes and risk of atrial fibrillation: findings from the HUNT study
- Prospective cohort study
- population-based
- registry-linked
Authors' conclusion
Women with history of HDP or LGA offspring are at higher risk of AF.
Study context
- Population
- Women ≥45 years in the population-based HUNT study linked with the Medical Birth Registry of Norway
- Participants
- 15,104 women · 34,674 births
- Exposure
- Women with vs without adverse pregnancy outcomes
- Outcome
- Validated AF
- Follow-up
- Median 12.9 years
Main finding
As reported in the abstract
AF
Each group vs without HDPHazard ratio (95% CI)
HDPwomen aged 45-65
2.03(1.27–3.24)
HDPwomen >65 years
0.95(0.57–1.60)
LGA
1.38(1.03–1.84)
Preterm birth
0.94(0.63–1.41)
SGA
0.90(0.66–1.23)
Observational data: associations, not effects.
Further findings
Mediation by post-pregnancy BMI (inverse odds ratio weighting)
- Post-pregnancy BMI might possibly explain share of hypertensive disorders of pregnancy (HDP)/LGA–atrial fibrillation (AF) associations
- ∼45%
Original publication
Adverse pregnancy outcomes and risk of atrial fibrillation: findings from the HUNT study. Eur J Prev Cardiol. Published 15 April 2025. doi:10.1093/eurjpc/zwaf233
Summarised from the published abstract; every number is checked against it