Valvular & structural heart diseaseCohort study
Aetiological Phenotypes of Atrial and Ventricular Secondary Tricuspid Regurgitation and Their Prognostic Implications: Insights from the CARE-TR Registry
- Registry-based cohort study
- multicentre
- 3 Italian centres
Authors' conclusion
In a real-world population with at least severe secondary TR, 22% had ASTR and showed better outcomes as compared to VSTR. Among patients with ASTR, combination of AF and HFpEF was common and associated with the worst prognosis. Among patients with VSTR, those with pre-capillary PH had the poorest outcomes, followed by those with LS-VHD.
Study context
- Population
- Patients with at least severe secondary tricuspid regurgitation, CARE-TR registry, 3 Italian centres22.1% ASTR, 77.9% VSTR
- Participants
- 648 patients
- Exposure
- Atrial vs ventricular secondary tricuspid regurgitation (TR)
- Outcome
- Composite of:
- Death
- HF hospitalization
- Follow-up
- 2 years
Main finding
Survival free from death or HF hospitalization
Adjusted hazard ratio
2.00
95% CI 1.33–3.02
P = 0.001
By group
VSTR vs ASTR
adjusted HR 2.00 (95% CI 1.33–3.02); P = 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Survival free from composite outcome, ASTR subgroups | AF + HFpEF 60.2% · AF 80.5% · HFpEF 83.6% |
| Survival free from composite outcome, VSTR subgroups | RVD 85% · HFpEF 65% · HFrEF/HFmrEF 54% · LS-VHD 39% · Pre-capillary PH 38% |
- Survival free from composite outcome, ASTR subgroups: p = 0.022
- Survival free from composite outcome, VSTR subgroups: p < 0.001
Death and Heart Failure (HF) hospitalization, overall cohort · median follow-up 498 days
- Deaths
- 118 (18.2%)
- HF hospitalization
- 153 (23.6%)
Original publication
Aetiological Phenotypes of Atrial and Ventricular Secondary Tricuspid Regurgitation and Their Prognostic Implications: Insights from the CARE-TR Registry. Eur J Heart Fail. Published 7 May 2025. doi:10.1002/ejhf.3678
Summarised from the published abstract; every number is checked against it