Heart failure & cardiomyopathies

Aficamten vs Metoprolol for Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM Rationale, Study Design, and Baseline Characteristics

JACC Heart FailPublication date not resolvedDesign and baseline characteristics paper of the MAPLE-HCM phase 3 randomised trial

Study context

Population
Adults with symptomatic obstructive hypertrophic cardiomyopathy (newly diagnosed or on standard-of-care (SOC) drugs)
Planned comparison
Aficamten vs metoprolol
Methodological detailsongoing, Rationale, design and baseline characteristics described; no results reported
  • Ongoing
  • Rationale, design and baseline characteristics described; no results reported

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Aficamten vs Metoprolol for Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM Rationale, Study Design, and Baseline Characteristics. JACC Heart Fail. doi:10.1016/j.jchf.2024.11.011

Summarised from the published abstract; every number is checked against it

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