Pulmonary vascular disease & thromboembolismCohort study
Age-Adjusted D-Dimer Cutoff Levels to Rule Out Deep Vein Thrombosis
- Prospective management outcome study
- multicentre
- multinational
- Deep vein thrombosis (DVT) prevalence 14%
Authors' conclusion
The age-adjusted D-dimer cutoff may safely rule out DVT and was associated with a larger number of patients in whom DVT could be effectively ruled out.
Study context
- Population
- Outpatients presenting to the ED with suspected DVT, 27 centres in Belgium, Canada, France and Switzerland, 2015–2022
- Participants
- 3,205 outpatients
- Exposure
- Age-adjusted D-dimer cutoff vs conventional 500 µg/L cutoff
- Outcome
- Adjudicated symptomatic VTE during follow-up in patients with DVT ruled out by D-dimer between 500 µg/L and their age-adjusted cutoff
- Follow-up
- 3 months
Main finding
As reported in the abstract
Failures (VTE) with D-dimer ≥500 µg/L but below age-adjusted cutoff
Age-adjusted cutoff
0%
0 events
Observational data: associations, not effects.
Further findings
| Outcome | Age-adjusted cutoff | Conventional cutoff |
|---|---|---|
| Negative D-dimer, non-high or unlikely clinical probability | Not reported in the abstract | 24.5% (95% CI 22.7%–26.4%) |
| Negative D-dimer, patients ≥75 years | 26.1% (95% CI 22.0%–30.8%) | 8.7% (95% CI 6.3%–12.0%) |
- Negative D-dimer, non-high or unlikely clinical probability: n = 2169
- Negative D-dimer, patients ≥75 years: n = 379
Negative D-dimer, patients ≥75 years
- No false-negative test results
Original publication
Age-Adjusted D-Dimer Cutoff Levels to Rule Out Deep Vein Thrombosis. JAMA. Published 3 February 2026. doi:10.1001/jama.2025.21561
Summarised from the published abstract; every number is checked against it